New York City
A hotel near Times Square, or at least within walking distance, as most attractions, amenities, shops, museums and theatres are all within 15-30mins walk of Times Square (and it's grid road system), means places are easy to find, and you won't get lost.
After people watching, neon sign watching, shopping and the odd street cabaret, it's time to move on from Times Square (you can always come back at night) to Macy's, the biggest store in the World. Then head down 34th Street to the iconic Empire State Building - go to the top for spectacular views across Manhattan, but get there early to avoid the queues. Walking up 5th Avenue, admire the shops and restaurants, off the side streets, until you get to Central Park, passing Grand Central Station on the way - worth a look!
7th Avenue brings us to the Rockefeller Centre, the skating rink, and a trip to the "Top of The Rock" will again give wonderful scenic views of Manhattan and beyond.
Take the Metro down to Battery Park ($5.00 return) for the ferries to Staten Island, the "Statue of Liberty" and Ellis Island. A short walk back finds the "9/11 Memorial" - the story of the Twin Towers and that fateful day - an emotional visit, but well worth it.
Catch a flight to arrive at lunchtime, and the immigration queues aren't too bad either. Overall, an exciting city, and a great place to spend a long weekend.